Ontology highlight
ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC6240287 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Li Dandan D Xiao Li L Ge Yuetan Y Fu Yu Y Zhang Wenqing W Cao Hanwei H Chen Binbin B Wang Haibin H Zhan Yan-Yan YY Hu Tianhui T
Molecular cancer 20181117 1
Tob1, a Tob/BTG anti-proliferative protein family member, functions as a tumour suppressor in many cancers. Here, we reveal a unique oncogenic role of Tob1 in colon cancer. Tob1 expression was upregulated during colon cancer progression, was significantly correlated with tumour size and tumour differentiation, and was a prognostic indicator of colon cancer. Unlike in other cancers, where nuclear Tob1 performs anticancer activity, Tob1 is predominantly localized in the cytosol of colon cancer cel ...[more]