Ontology highlight
ABSTRACT:
SUBMITTER: Nantie LB
PROVIDER: S-EPMC6240317 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nantie Leah B LB Young Randee E RE Paltzer Wyatt G WG Zhang Yan Y Johnson Randy L RL Verheyden Jamie M JM Sun Xin X
Development (Cambridge, England) 20181109 21
Lung growth to its optimal size at birth is driven by reiterative airway branching followed by differentiation and expansion of alveolar cell types. How this elaborate growth is coordinated with the constraint of the chest is poorly understood. Here, we investigate the role of Hippo signaling, a cardinal pathway in organ size control, in mouse lung development. Unexpectedly, we found that epithelial loss of the Hippo kinase genes <i>Lats1</i> and <i>Lats2</i> (<i>Lats1/2</i>) leads to a striking ...[more]