Ontology highlight
ABSTRACT:
SUBMITTER: Eftekharzadeh B
PROVIDER: S-EPMC6240334 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Neuron 20180901 5
Tau is the major constituent of neurofibrillary tangles in Alzheimer's disease (AD), but the mechanism underlying tau-associated neural damage remains unclear. Here, we show that tau can directly interact with nucleoporins of the nuclear pore complex (NPC) and affect their structural and functional integrity. Pathological tau impairs nuclear import and export in tau-overexpressing transgenic mice and in human AD brain tissue. Furthermore, the nucleoporin Nup98 accumulates in the cell bodies of s ...[more]