Dataset Information

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.

ABSTRACT:

Purpose

A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART).

Materials and methods

From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among subgroups.

Results

From the 6493 participants, 24072 person-years (PY) of follow-up were contributed during 2008-2016. The incidence rates of hypertension were 4.6 and 3.6 per 100 PY for abacavir and non-abacavir ART users, respectively. The population attributable fraction of abacavir use on hypertension was 12%. Abacavir exposure did not elevate the risk of hypertension among overall study population [HR, 1.2 (95% CI, 1.0-1.4), p=0.061]. However, those with poor ART adherence, defined as a medication possession ratio <50% [HR, 1.9 (95% CI, 1.5-2.4), p<0.0001] or requiring prophylactic antibiotics [HR, 1.2 (95% CI, 1.0-1.3), p=0.023], were at risk of hypertension induced by abacavir, as were men, individuals aged ?40 years, and patients visiting tertiary hospitals in urban areas.

Conclusion

When present, poor ART adherence, requiring prophylactic antibiotics, male sex, and older age may warrant additional concern for hypertension in patients treated with abacavir.

SUBMITTER: Kim J

PROVIDER: S-EPMC6240567 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.

Kim Jungmee J Bang Ji Hwan JH Shin Ju Young JY Yang Bo Ram BR Lee Joongyub J Park Byung Joo BJ

Yonsei medical journal 20181201 10

<h4>Purpose</h4>A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART).<h4>Materials and methods</h4>From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertension at baseline were ...[more]

PMID: 30450860

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Dataset Information

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.

Purpose

Materials and methods

Results

Conclusion

Publications

Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study.

Similar Datasets

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