Dataset Information

Patterns of homozygosity in insular and continental goat breeds.

ABSTRACT:

Background

Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds.

Results

Among the breeds analysed, number and total length of ROH varied considerably and depending on breeds, ROH could cover a substantial fraction of the genome (up to 1.6 Gb in Icelandic goats). When compared with their continental counterparts, goats from Iceland, Madagascar, La Palma and Ireland (Bilberry and Arran) displayed a significant increase in ROH coverage, ROH number and F_ROH values (P value ConclusionsThese results indicate that the effects of insularization on the patterns of homozygosity are variable. Goats raised in Madagascar, Iceland, Ireland (Bilberry and Arran) and La Palma, show high levels of homozygosity, whereas those bred in Mediterranean islands display patterns of homozygosity that are similar to those found in continental populations. These results indicate that the diversity of insular goat populations is modulated by multiple factors such as geographic distribution, population size, demographic history, trading and breed management.

SUBMITTER: Cardoso TF

PROVIDER: S-EPMC6241035 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Patterns of homozygosity in insular and continental goat breeds.

Cardoso Taina F TF Amills Marcel M Bertolini Francesca F Rothschild Max M Marras Gabriele G Boink Geert G Jordana Jordi J Capote Juan J Carolan Sean S Hallsson Jón H JH Kantanen Juha J Pons Agueda A Lenstra Johannes A JA

Genetics, selection, evolution : GSE 20181119 1

<h4>Background</h4>Genetic isolation of breeds may result in a significant loss of diversity and have consequences on health and performance. In this study, we examined the effect of geographic isolation on caprine genetic diversity patterns by genotyping 480 individuals from 25 European and African breeds with the Goat SNP50 BeadChip and comparing patterns of homozygosity of insular and nearby continental breeds.<h4>Results</h4>Among the breeds analysed, number and total length of ROH varied co ...[more]

PMID: 30449277

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Dataset Information

Patterns of homozygosity in insular and continental goat breeds.

Background

Results

Publications

Patterns of homozygosity in insular and continental goat breeds.

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