Ontology highlight
ABSTRACT:
SUBMITTER: You M
PROVIDER: S-EPMC6241347 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
You Mengli M Gao Jiaming J Jin Jianhua J Hou Yongzhong Y
Journal of oncology 20181104
PPAR<i>α</i> (peroxisome-proliferator-activated receptor <i>α</i>) plays a critical role in regulation of inflammation and cancer, while the regulatory mechanism of PPAR<i>α</i> on cancer cell autophagy is still unclear. Here we found that PPAR<i>α</i> enhanced autophagy in HEK293T, SW480, and Hela cell lines, which was independent of PPAR<i>α</i> transcription activity. PPAR<i>α</i> induced antiapoptotic Bcl2 protein degradation resulting in release of the Beclin-1/VPS34 complex. Consistently, ...[more]