Dataset Information

Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

ABSTRACT: Background:There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer. Methods:We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2003. A total of 713 incident colon cancer cases were matched, using risk-set sampling, to 713 controls on age, sex, study centre, fasting status and hormonal therapy use. The amount of total physical activity during the past year was expressed in metabolic equivalent of task [MET]-h/week. Anthropometric measurements and blood samples were collected at study baseline. Results:High physical activity was associated with a lower risk of colon cancer: relative risk ?91 MET-h/week vs <91 MET-h/week = 0.75 [95% confidence interval (CI): 0.57 to 0.96]. In mediation analyses, this association was accounted for by waist circumference: proportion explained effect (PEE) = 17%; CI: 4% to 52%; and the biomarkers soluble leptin receptor (sOB-R): PEE = 15%; 95% CI: 1% to 50% and 5-hydroxyvitamin D (25[OH]D): PEE = 30%; 95% CI: 12% to 88%. In combination, these factors explained 45% (95% CI: 20% to 125%) of the association. Beyond waist circumference, sOB-R and 25[OH]D additionally explained 10% (95% CI: 1%; 56%) and 23% (95% CI: 6%; 111%) of the association, respectively. Conclusions:Promoting physical activity, particularly outdoors, and maintaining metabolic health and adequate vitamin D levels could represent a promising strategy for colon cancer prevention.

SUBMITTER: Aleksandrova K

PROVIDER: S-EPMC6241846 | biostudies-literature | 2017 Dec

REPOSITORIES: biostudies-literature

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Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

Aleksandrova Krasimira K Jenab Mazda M Leitzmann Michael M Bueno-de-Mesquita Bas B Kaaks Rudolf R Trichopoulou Antonia A Bamia Christina C Lagiou Pagona P Rinaldi Sabina S Freisling Heinz H Carayol Marion M Pischon Tobias T Drogan Dagmar D Weiderpass Elisabete E Jakszyn Paula P Overvad Kim K Dahm Christina C CC Tjønneland Anne A Bouton-Ruault Marie-Christine MC Kühn Tilman T Peppa Eleni E Valanou Elissavet E La Vecchia Carlo C Palli Domenico D Panico Salvatore S Sacerdote Carlotta C Agnoli Claudia C Tumino Rosario R May Anne A van Vulpen Jonna J Benjaminsen Borch Kristin K Oluwafemi Oyeyemi Sunday S Quirós J Ramón JR Bonet Catalina C Sánchez María-José MJ Dorronsoro Miren M Navarro Carmen C Barricarte Aurelio A van Guelpen Bethany B Wennberg Patrik P Key Timothy J TJ Khaw Kay-Tee KT Wareham Nicholas N Assi Nada N Ward Heather A HA Aune Dagfinn D Riboli Elio E Boeing Heiner H

International journal of epidemiology 20171201 6

<h4>Background</h4>There is convincing evidence that high physical activity lowers the risk of colon cancer; however, the underlying biological mechanisms remain largely unknown. We aimed to determine the extent to which body fatness and biomarkers of various biologically plausible pathways account for the association between physical activity and colon cancer.<h4>Methods</h4>We conducted a nested case-control study in a cohort of 519 978 men and women aged 25 to 70 years followed from 1992 to 2 ...[more]

PMID: 29025032

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Dataset Information

Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

Publications

Physical activity, mediating factors and risk of colon cancer: insights into adiposity and circulating biomarkers from the EPIC cohort.

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