Ontology highlight
ABSTRACT:
SUBMITTER: Lin SH
PROVIDER: S-EPMC6242332 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Lin Sheng-Hsuan SH Young Jessica G JG Logan Roger R VanderWeele Tyler J TJ
Statistics in medicine 20170815 26
We propose an approach to conduct mediation analysis for survival data with time-varying exposures, mediators, and confounders. We identify certain interventional direct and indirect effects through a survival mediational g-formula and describe the required assumptions. We also provide a feasible parametric approach along with an algorithm and software to estimate these effects. We apply this method to analyze the Framingham Heart Study data to investigate the causal mechanism of smoking on mort ...[more]