Ontology highlight
ABSTRACT:
SUBMITTER: Perez-Mazliah D
PROVIDER: S-EPMC6242553 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
eLife 20181102
A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, <i>Plasmodium chaba ...[more]