Unknown

Dataset Information

0

Plasmodium-specific atypical memory B cells are short-lived activated B cells.

ABSTRACT: A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, Plasmodium chabaudi. In combination with a mosquito-initiated P. chabaudi infection, we show that Plasmodium-specific atypical memory B cells are short-lived and disappear upon natural resolution of chronic infection. These cells show features of activation, proliferation, DNA replication, and plasmablasts. Our data demonstrate that Plasmodium-specific atypical memory B cells are not a subset of long-lived memory B cells, but rather short-lived activated cells, and part of a physiologic ongoing B-cell response.

SUBMITTER: Perez-Mazliah D 

PROVIDER: S-EPMC6242553 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

A subset of atypical memory B cells accumulates in malaria and several infections, autoimmune disorders and aging in both humans and mice. It has been suggested these cells are exhausted long-lived memory B cells, and their accumulation may contribute to poor acquisition of long-lasting immunity to certain chronic infections, such as malaria and HIV. Here, we generated an immunoglobulin heavy chain knock-in mouse with a BCR that recognizes MSP1 of the rodent malaria parasite, <i>Plasmodium chaba  ...[more]

Similar Datasets

Transcriptomics Plasmodium-specific atypical memory B cells are short-lived activated B cells
2018-11-01 | GSE115155 | GEO
Genomics Plasmodium-specific atypical memory B cells are short-lived activated B cells
| PRJNA473982 | ENA
Unknown Long-lived Plasmodium falciparum specific memory B cells in naturally exposed Swedish travelers.
| S-EPMC4114544 | biostudies-literature
Unknown KLRG1<sup>+</sup> Memory CD8 T Cells Combine Properties of Short-Lived Effectors and Long-Lived Memory.
| S-EPMC7415731 | biostudies-literature
Unknown Persistence of Long-lived Memory B Cells specific to Duffy Binding Protein in individuals exposed to Plasmodium vivax.
| S-EPMC5973932 | biostudies-literature
Unknown Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies.
| S-EPMC3570107 | biostudies-literature
Transcriptomics KLRG1+ Memory CD8 T cells Combine Properties of Short-lived Effectors and Long-lived Memory
2020-08-26 | GSE152841 | GEO
Unknown Highly heterogeneous, activated, and short-lived regulatory T cells during chronic filarial infection.
| S-EPMC4809647 | biostudies-literature
Unknown Atypical memory B-cells and autoantibodies correlate with anemia during Plasmodium vivax complicated infections.
| S-EPMC7392348 | biostudies-literature
Unknown Atypical memory B-cells are associated with Plasmodium falciparum anemia through anti-phosphatidylserine antibodies.
| S-EPMC6853636 | biostudies-literature