Ontology highlight
ABSTRACT:
SUBMITTER: Delgado-Benito V
PROVIDER: S-EPMC6242708 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Molecular cell 20181004 4
Class switch recombination (CSR) is a DNA recombination reaction that diversifies the effector component of antibody responses. CSR is initiated by activation-induced cytidine deaminase (AID), which targets transcriptionally active immunoglobulin heavy chain (Igh) switch donor and acceptor DNA. The 3' Igh super-enhancer, 3' regulatory region (3'RR), is essential for acceptor region transcription, but how this function is regulated is unknown. Here, we identify the chromatin reader ZMYND8 as an e ...[more]