Ontology highlight
ABSTRACT:
SUBMITTER: Dutta DJ
PROVIDER: S-EPMC6243273 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Dutta Dipankar J DJ Woo Dong Ho DH Lee Philip R PR Pajevic Sinisa S Bukalo Olena O Huffman William C WC Wake Hiroaki H Basser Peter J PJ SheikhBahaei Shahriar S Lazarevic Vanja V Smith Jeffrey C JC Fields R Douglas RD
Proceedings of the National Academy of Sciences of the United States of America 20181029 46
The speed of impulse transmission is critical for optimal neural circuit function, but it is unclear how the appropriate conduction velocity is established in individual axons. The velocity of impulse transmission is influenced by the thickness of the myelin sheath and the morphology of electrogenic nodes of Ranvier along axons. Here we show that myelin thickness and nodal gap length are reversibly altered by astrocytes, glial cells that contact nodes of Ranvier. Thrombin-dependent proteolysis o ...[more]