Ontology highlight
ABSTRACT:
SUBMITTER: Yang W
PROVIDER: S-EPMC6243375 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Yang Weiming W Ao Minghui M Hu Yingwei Y Li Qing Kay QK Zhang Hui H
Molecular systems biology 20181120 11
Protein glycosylation is one of the most abundant post-translational modifications. However, detailed analysis of O-linked glycosylation, a major type of protein glycosylation, has been severely impeded by the scarcity of suitable methodologies. Here, a chemoenzymatic method is introduced for the site-specific extraction of O-linked glycopeptides (EXoO), which enabled the mapping of over 3,000 O-linked glycosylation sites and definition of their glycans on over 1,000 proteins in human kidney tis ...[more]