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Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats.


ABSTRACT: Monocytes are involved in adverse left ventricular (LV) remodelling following myocardial infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in monocytes that relate to post-MI healing and evaluated intervention with the observed gene activity in a rat MI model. In 51 MI patients treated by primary percutaneous coronary intervention (PCI), the change in LV end-diastolic volume index (EDVi) from baseline to 4-month follow-up was assessed using cardiovascular magnetic resonance imaging (CMR). Circulating monocytes were collected at day 5 (Arterioscler Thromb Vasc Biol 35:1066-1070, 2015; Cell Stem Cell 16:477-487, 2015; Curr Med Chem 13:1877-1893, 2006) after primary PCI for transcriptome analysis. Transcriptional profiling and pathway analysis revealed that patients with a decreased LV EDVi showed an induction of type I interferon (IFN) signalling (type I IFN pathway: P value?

SUBMITTER: Ter Horst EN 

PROVIDER: S-EPMC6244641 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Elevated monocyte-specific type I interferon signalling correlates positively with cardiac healing in myocardial infarct patients but interferon alpha application deteriorates myocardial healing in rats.

Ter Horst Ellis N EN   Krijnen Paul A J PAJ   Hakimzadeh Nazanin N   Robbers Lourens F H J LFHJ   Hirsch Alexander A   Nijveldt Robin R   Lommerse Ingrid I   Fontijn Ruud D RD   Meinster Elisa E   Delewi Ronak R   van Royen Niels N   Zijlstra Felix F   van Rossum Albert C AC   van der Schoot C Ellen CE   van der Pouw Kraan Tineke C T M TCTM   Horrevoets Anton J AJ   van der Laan Anja M AM   Niessen Hans W M HWM   Piek Jan J JJ  

Basic research in cardiology 20181112 1


Monocytes are involved in adverse left ventricular (LV) remodelling following myocardial infarction (MI). To provide therapeutic opportunities we aimed to identify gene transcripts in monocytes that relate to post-MI healing and evaluated intervention with the observed gene activity in a rat MI model. In 51 MI patients treated by primary percutaneous coronary intervention (PCI), the change in LV end-diastolic volume index (EDVi) from baseline to 4-month follow-up was assessed using cardiovascula  ...[more]

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