Long-term toxicity of cisplatin in germ-cell tumor survivors.

ABSTRACT:

Context

Testicular germ-cell tumors (GCT) are highly curable. A multidisciplinary approach, including cisplatin-based chemotherapy has resulted in cure in the majority of patients with GCT. Thus, the life expectancy of survivors will extend to many decades post-diagnosis. Late treatment toxicities associated with cisplatin-based chemotherapy may impact their future health.

Objective

To systematically evaluate evidence regarding the long-term toxicity of cisplatin in GCT survivors.

Evidence acquisition

We carried out a critical review of PubMed/Medline in February 2017 according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) statement. Identified reports were reviewed according to the Consolidated Standards of Reporting Trials (CONSOR

SUBMITTER: Chovanec M 

PROVIDER: S-EPMC6246726 | biostudies-literature | 2017 Nov

REPOSITORIES: biostudies-literature