Ontology highlight
ABSTRACT:
SUBMITTER: Schwartz PJ
PROVIDER: S-EPMC6247660 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Schwartz Peter J PJ Crotti Lia L George Alfred L AL
European heart journal 20181101 44
Genetic conditions, even those associated with identical gene mutations, can present with variable clinical manifestations. One widely accepted explanation for this phenomenon is the existence of genetic factors capable of modifying the consequences of disease-causing mutations (modifier genes). Here, we address the concepts and principles by which genetic factors may be involved in modifying risk for cardiac arrhythmia, then discuss the current knowledge and interpretation of their contribution ...[more]