Anti-Inflammatory Effect of Atorvastatin on the Kidney Graft of Living Donor Transplants.

ABSTRACT: BACKGROUND Recent studies have demonstrated that statins have anti-inflammatory and immunomodulatory properties, which could be considered beneficial in kidney transplantations. This study assesses the anti-inflammatory effect of atorvastatin on the kidney grafts of living donor transplants. MATERIAL AND METHODS In a randomized clinical trial, kidney donors were divided into 2 groups. The study group constituted 24 donors who received 40 mg atorvastatin, and 24 donors who received a placebo control, 4 weeks prior to transplantation. Serum C-reactive protein (CRP) levels were measured before and after atorvastatin administration. CRP and renal function of kidney recipients were measured at baseline and 1, 6, and 24 hours after transplantation. RESULTS After 4 weeks of treatment, the CRP lev

SUBMITTER: Fuentes-Orozco C 

PROVIDER: S-EPMC6248064 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature