Ontology highlight
ABSTRACT:
SUBMITTER: Yang L
PROVIDER: S-EPMC6248878 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Yang Linlin L Kim Hyun Bum HB Sul Jai-Yoon JY Yeldell Sean B SB Eberwine James H JH Dmochowski Ivan J IJ
Chembiochem : a European journal of chemical biology 20180417 12
Light-activated ("caged") antisense oligonucleotides are powerful molecules for regulating gene expression at submicron spatial resolution through the focal modulation of endogenous cellular processes. Cyclized caged oligos are particularly promising structures because of their inherent stability and similarity to naturally occurring circular DNA and RNA molecules. Here, we introduce an efficient route for cyclizing an antisense oligodeoxynucleotide incorporating a photocleavable linker. Oligo c ...[more]