Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC6249058 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Li Shiyang S Bostick John W JW Ye Jian J Qiu Ju J Zhang Bin B Urban Joseph F JF Avram Dorina D Zhou Liang L
Immunity 20181113 5
Innate lymphoid cells (ILCs) are important for mucosal immunity. The intestine harbors all ILC subsets, but how these cells are balanced to achieve immune homeostasis and mount appropriate responses during infection remains elusive. Here, we show that aryl hydrocarbon receptor (Ahr) expression in the gut regulates ILC balance. Among ILCs, Ahr is most highly expressed by gut ILC2s and controls chromatin accessibility at the Ahr locus via positive feedback. Ahr signaling suppresses Gfi1 transcript ...[more]