Browse
Submit Data
Databases
API
Help

Dataset Information

26 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions.

ABSTRACT: Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF₃ and PrF₃ nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR via a synergistic action of an ensemble of tiny size nanoparticles (

SUBMITTER: Semashko VV

PROVIDER: S-EPMC6249154 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Tiny Rare-Earth Fluoride Nanoparticles Activate Tumour Cell Growth via Electrical Polar Interactions.

Semashko Vadim V VV Pudovkin Maksim S MS Cefalas Alkiviadis-Constantinos AC Zelenikhin Pavel V PV Gavriil Vassilios E VE Nizamutdinov Alexei S AS Kollia Zoe Z Ferraro Angelo A Sarantopoulou Evangelia E

Nanoscale research letters 20181121 1

Localised extracellular interactions between nanoparticles and transmembrane signal receptors may well activate cancer cell growth. Herein, tiny LaF<sub>3</sub> and PrF<sub>3</sub> nanoparticles in DMEM+FBS suspensions stimulated tumour cell growth in three different human cell lines (A549, SW837 and MCF7). Size distribution of nanoparticles, activation of AKT and ERK signalling pathways and viability tests pointed to mechanical stimulation of ligand adhesion binding sites of integrins and EGFR ...[more]

PMID: 30465280

Similar Datasets

Synthesis of rare-earth metal and rare-earth metal-fluoride nanoparticles in ionic liquids and propylene carbonate.

Project description:Decomposition of rare-earth tris(N,N'-diisopropyl-2-methylamidinato)metal(III) complexes [RE{MeC(N(iPr)2)}3] (RE(amd)3; RE = Pr(III), Gd(III), Er(III)) and tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III) (Eu(dpm)3) induced by microwave heating in the ionic liquids (ILs) 1-butyl-3-methylimidazolium tetrafluoroborate ([BMIm][BF4]), 1-butyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide ([BMIm][NTf2]) and in propylene carbonate (PC) yield oxide-free rare-earth metal nanoparticles (RE-NPs) in [BMIm][NTf2] and PC for RE = Pr, Gd and Er or rare-earth metal-fluoride nanoparticles (REF3-NPs) in the fluoride-donating IL [BMIm][BF4] for RE = Pr, Eu, Gd and Er. The crystalline phases and the absence of significant oxide impurities in RE-NPs and REF3-NPs were verified by powder X-ray diffraction (PXRD), selected area electron diffraction (SAED) and high-resolution X-ray photoelectron spectroscopy (XPS). The size distributions of the nanoparticles were determined by transmission electron microscopy (TEM) and high-angle annular dark-field scanning transmission electron microscopy (HAADF-STEM) to an average diameter of (11 ± 6) to (38 ± 17) nm for the REF3-NPs from [BMIm][BF4]. The RE-NPs from [BMIm][NTf2] or PC showed diameters of (1.5 ± 0.5) to (5 ± 1) nm. The characterization was completed by energy-dispersive X-ray spectroscopy (EDX).

| S-EPMC6036975 | biostudies-literature

Helix-constructed polar rare-earth iodate fluoride as a laser nonlinear optical multifunctional material.

Project description:The first trivalent rare-earth iodate fluoride nonlinear optical (NLO) crystal, Y(IO3)2F (YIF), was successfully designed and synthesized, featuring polarization-favorable helical chains constructed from trans-YO6F2 polyhedra and IO3 groups. It exhibited a suitable balance of a wide transparency range of 0.26-10.0 μm, high laser damage threshold (LDT) of 39.6 × AgGaS2, and moderate second harmonic generation (SHG) effect of 2 × KDP. A series of doped RE:YIF (RE = Pr, Nd, Dy, Ho, Er, Tm, and Yb) crystals were easily synthesized benefiting from the spring-shaped helix structure, which possess wide absorption and emission peaks as well as long lifetime, especially in the visible and near-infrared regions. Particularly, the remarkable fluorescence properties of Nd and Yb doped YIF crystals are comparable to and even better than those of traditional self-frequency doubling (SFD) crystals such as YAB, YCOB, and GdCOB. Thus, these RE-doped YIF crystals are promising laser SFD crystals. This work also indicated that constructing helical chains should be an effective strategy for the design of inorganic polar materials.

| S-EPMC7553043 | biostudies-literature

Rare earth elements activate endocytosis in plant cells.

Project description:It has long been observed that rare earth elements (REEs) regulate multiple facets of plant growth and development. However, the underlying mechanisms remain largely unclear. Here, using electron microscopic autoradiography, we show the life cycle of a light REE (lanthanum) and a heavy REE (terbium) in horseradish leaf cells. Our data indicate that REEs were first anchored on the plasma membrane in the form of nanoscale particles, and then entered the cells by endocytosis. Consistently, REEs activated endocytosis in plant cells, which may be the cellular basis of REE actions in plants. Moreover, we discovered that a portion of REEs was successively released into the cytoplasm, self-assembled to form nanoscale clusters, and finally deposited in horseradish leaf cells. Taken together, our data reveal the life cycle of REEs and their cellular behaviors in plant cells, which shed light on the cellular mechanisms of REE actions in living organisms.

| S-EPMC4156694 | biostudies-literature

Arabinogalactan protein-rare earth element complexes activate plant endocytosis.

Project description:Endocytosis is essential to all eukaryotes, but how cargoes are selected for internalization remains poorly characterized. Extracellular cargoes are thought to be selected by transmembrane receptors that bind intracellular adaptors proteins to initiate endocytosis. Here, we report a mechanism for clathrin-mediated endocytosis (CME) of extracellular lanthanum [La(III)] cargoes, which requires extracellular arabinogalactan proteins (AGPs) that are anchored on the outer face of the plasma membrane. AGPs were colocalized with La(III) on the cell surface and in La(III)-induced endocytic vesicles in Arabidopsis leaf cells. Superresolution imaging showed that La(III) triggered AGP movement across the plasma membrane. AGPs were then colocalized and physically associated with the μ subunit of the intracellular adaptor protein 2 (AP2) complexes. The AGP-AP2 interaction was independent of CME, whereas AGP's internalization required CME and AP2. Moreover, we show that AGP-dependent endocytosis in the presence of La(III) also occurred in human cells. These findings indicate that extracellular AGPs act as conserved CME cargo receptors, thus challenging the current paradigm about endocytosis of extracellular cargoes.

| S-EPMC6628639 | biostudies-literature

Engineering Bright and Mechanosensitive Alkaline-Earth Rare-Earth Upconverting Nanoparticles.

Project description:Upconverting nanoparticles (UCNPs) are an emerging platform for mechanical force sensing at the nanometer scale. An outstanding challenge in realizing nanometer-scale mechano-sensitive UCNPs is maintaining a high mechanical force responsivity in conjunction with bright optical emission. This Letter reports mechano-sensing UCNPs based on the lanthanide dopants Yb3+ and Er3+, which exhibit a strong ratiometric change in emission spectra and bright emission under applied pressure. We synthesize and analyze the pressure response of five different types of nanoparticles, including cubic NaYF4 host nanoparticles and alkaline-earth host materials CaLuF, SrLuF, SrYbF, and BaLuF, all with lengths of 15 nm or less. By combining optical spectroscopy in a diamond anvil cell with single-particle brightness, we determine the noise equivalent sensitivity (GPa/√Hz) of these particles. The SrYb0.72Er0.28F@SrLuF particles exhibit an optimum noise equivalent sensitivity of 0.26 ± 0.04 GPa/√Hz. These particles present the possibility of robust nanometer-scale mechano-sensing.

| S-EPMC9587901 | biostudies-literature

Electrical Conductivity in a Porous, Cubic Rare-Earth Catecholate.

Project description:Electrically conductive metal-organic frameworks (MOFs) provide a rare example of porous materials that can efficiently transport electrical current, a combination that is favorable for a variety of technological applications. The vast majority of such MOFs are highly anisotropic in both their structures and properties: Only two electrically conductive MOFs reported to date exhibit cubic structures that enable isotropic charge transport. Here we report a new family of intrinsically porous frameworks made from rare-earth nitrates and hexahydroxytriphenylene. The materials feature a novel hexanuclear secondary building unit and form cubic, porous, and intrinsically conductive structures, with electrical conductivities reaching 10-5 S/cm and surface areas of up to 780 m2/g. By expanding the list of MOFs with isotropic charge transport, these results will help us to improve our understanding of design strategies for porous electronic materials.

| S-EPMC7311054 | biostudies-literature

Sorting Phenomena and Chirality Transfer in Fluoride-Bridged Macrocyclic Rare Earth Complexes.

Project description:The reaction of fluoride anions with mononuclear lanthanide(III) and yttrium(III) hexaaza-macrocyclic complexes results in the formation of dinuclear fluoride-bridged complexes. As indicated by X-ray crystal structures, in these complexes two metal ions bound by the macrocycles are linked by two or three bridging fluoride anions, depending on the type of the macrocycle. In the case of the chiral hexaaza-macrocycle L1 derived from trans-1,2-diaminocyclohexane, the formation of these μ2-fluorido dinuclear complexes is accompanied by enantiomeric self-recognition of macrocyclic units. In contrast, this kind of recognition is not observed in the case of complexes of the chiral macrocycle L2 derived from 1,2-diphenylethylenediamine. The reaction of fluoride with a mixture of mononuclear complexes of L1 and L2, containing two different Ln(III) ions, results in narcissistic sorting of macrocyclic units. Conversely, a similar reaction involving mononuclear complexes of L1 and complexes of achiral macrocycle L3 based on ethylenediamine results in sociable sorting of macrocyclic units and preferable formation of heterodinuclear complexes. In addition, formation of these heterodinuclear complexes is accompanied by chirality transfer from the chiral macrocycle L1 to the achiral macrocycle L3 as indicated by CPL and CD spectra.

| S-EPMC8653217 | biostudies-literature

Chemoselective Polymerization of Polar Divinyl Monomers with Rare-Earth/Phosphine Lewis Pairs.

Project description:This work reports the chemoselective polymerization of polar divinyl monomers, including allyl methacrylate (AMA), vinyl methacrylate (VMA), and 4-vinylbenzyl methacrylate (VBMA), by using simple Lewis pairs comprised of homoleptic rare-earth (RE) aryloxide complexes RE(OAr)₃ (RE = Sc (1), Y (2), Sm (3), La (4), Ar = 2,6-tBu₂C₆H₃) and phosphines PR₃ (R = Ph, Cy, Et, Me). Catalytic activities of polymerizations relied heavily upon the cooperation of Lewis acid and Lewis base components. The produced polymers were soluble in common organic solvents and often had a narrow molecular weight distribution. A highly syndiotactic poly(allyl methacrylate) (PAMA) with rr ~88% could be obtained by the scandium complex 1/PEt₃ pair at -30 °C. In the case of poly(4-vinylbenzyl methacrylate) (PVBMA), it could be post-functionalized with PhCH₂SH. Mechanistic study, including the isolation of the zwitterionic active species and the end-group analysis, revealed that the frustrated Lewis pair (FLP)-type addition was the initiating step in the polymerization.

| S-EPMC6017840 | biostudies-literature

Multi-component Toxicological Study on Rare Earth Upconversion Nanoparticles

Project description:UCNPs@PEG was divided into three groups, 0.0 mg/mL, 0.25 mg/mL, 1.0 mg/mL, and each concentration was repeated for three groups. After co-culture with AML12 cells for 24h, the medium was removed by pipette gun, and sterilized PBS was added for washing 3 times. 300μ L RIPA cell lysate was added to the culture dish. The lysed cells were scraped off with sterile cell scraper, and the lysed cell solution was sucked into the cryopreservation tube.(TandemMassTags) Labeled protein for proteomic study. First extract the total protein in cells, then do concentration determination and SDS-PAGE detection, then use TMT labeled protein after protease hydrolysis, label samples after uniform mixing chromatography separation, and then LC-MS/MS analysis. Chromatographic reaction conditions: A phase H2O-FA (99.9: 0.1, v/v), Phase B ACN-H2O-FA (80: 19.9: 0.1, v/v/v), mass resolution 60000, scan charge-to-mass ratio range 350-1500, collision energy 32, resolution 45000, automatic gain control 2e5. Functional annotation analysis of identified proteins was carried out using common protein databases. Differential proteins were screened and GO, KEGG and interaction analysis were carried out respectively. Cluster thermomap and Veen analysis were used to analyze differential data.

2024-07-23 | PXD054163 |

Biotransformation of rare earth oxide nanoparticles eliciting microbiota imbalance.

Project description:BackgroundDisruption of microbiota balance may result in severe diseases in animals and phytotoxicity in plants. While substantial concerns have been raised on engineered nanomaterial (ENM) induced hazard effects (e.g., lung inflammation), exploration of the impacts of ENMs on microbiota balance holds great implications.ResultsThis study found that rare earth oxide nanoparticles (REOs) among 19 ENMs showed severe toxicity in Gram-negative (G-) bacteria, but negligible effects in Gram-positive (G+) bacteria. This distinct cytotoxicity was disclosed to associate with the different molecular initiating events of REOs in G- and G+ strains. La2O3 as a representative REOs was demonstrated to transform into LaPO4 on G- cell membranes and induce 8.3% dephosphorylation of phospholipids. Molecular dynamics simulations revealed the dephosphorylation induced more than 2-fold increments of phospholipid diffusion constant and an unordered configuration in membranes, eliciting the increments of membrane fluidity and permeability. Notably, the ratios of G-/G+ reduced from 1.56 to 1.10 in bronchoalveolar lavage fluid from the mice with La2O3 exposure. Finally, we demonstrated that both IL-6 and neutrophil cells showed strong correlations with G-/G+ ratios, evidenced by their correlation coefficients with 0.83 and 0.92, respectively.ConclusionsThis study deciphered the distinct toxic mechanisms of La2O3 as a representative REO in G- and G+ bacteria and disclosed that La2O3-induced membrane damages of G- cells cumulated into pulmonary microbiota imbalance exhibiting synergistic pulmonary toxicity. Overall, these findings offered new insights to understand the hazard effects induced by REOs.

| S-EPMC8077720 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data