Ontology highlight
ABSTRACT:
SUBMITTER: Cui C
PROVIDER: S-EPMC6249344 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Cui Cheng C Su Min M Lin Yujun Y Lai Laijun L
Frontiers in immunology 20181115
T cell responses are fine-tuned by co-stimulatory and co-inhibitory molecules. Among the T cell regulators, the B7 family members are of central importance. The recent success in targeting the B7 family molecules for the treatment of immune-related diseases has attracted intense interest in identifying additional B7-related molecules. In this study, we describe CD300c as a novel T cell co-inhibitory molecule that shares significant sequence homology with existing B7 family members. CD300c protei ...[more]