Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6249349 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Wang Yafen Y Liu Chaoxing C Wu Fan F Zhang Xiong X Liu Sheng S Chen Zonggui Z Zeng Weiwu W Yang Wei W Zhang Xiaolian X Zhou Yu Y Weng Xiaocheng X Wu Zhiguo Z Zhou Xiang X
iScience 20181102
Chemical modifications to nucleobases have a great influence on various cellular processes, by making gene regulation more complex, thus indicating their profound impact on aspects of heredity, growth, and disease. Here, we provide the first genome-wide map of 5-formyluracil (5fU) in living tissues and evaluate the potential roles for 5fU in genomics. We show that an azido derivative of (2-benzimidazolyl)acetonitrile has high selectivity for enriching 5fU-containing genomic DNA. The results have ...[more]