Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6249567 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Liu Ying Y Ye Ling L Lin Fang F Gomaa Yasmine Y Flyer David D Carrion Ricardo R Patterson Jean L JL Prausnitz Mark R MR Smith Gale G Glenn Gregory G Wu Hua H Compans Richard W RW Yang Chinglai C
The Journal of infectious diseases 20181101 suppl_5
In this study, we investigated immune responses induced by purified Ebola virus (EBOV) soluble glycoprotein (sGP) subunit vaccines via intradermal immunization with microneedle (MN) patches in comparison with intramuscular (IM) injection in mice. Our results showed that MN delivery of EBOV sGP was superior to IM injection in eliciting higher levels and longer lasting antibody responses against EBOV sGP and GP antigens. Moreover, sGP-specific immune responses induced by MN or IM immunizations wer ...[more]