Ontology highlight
ABSTRACT:
SUBMITTER: Lavender KJ
PROVIDER: S-EPMC6249575 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lavender Kerry J KJ Williamson Brandi N BN Saturday Greg G Martellaro Cynthia C Griffin Amanda A Hasenkrug Kim J KJ Feldmann Heinz H Prescott Joseph J
The Journal of infectious diseases 20181101 suppl_5
Ebola virus (EBOV) and Marburg virus (MARV) outbreaks are highly lethal, and infection results in a hemorrhagic fever with complex etiology. These zoonotic viruses dysregulate the immune system to cause disease, in part by replicating within myeloid cells that would normally innately control viral infection and shape the adaptive immune response. We used triple knockout (TKO)-bone marrow, liver, thymus (BLT) humanized mice to recapitulate the early in vivo human immune response to filovirus infe ...[more]