Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.
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ABSTRACT:
SUBMITTER: Ilinykh PA
PROVIDER: S-EPMC6249583 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.
Ilinykh Philipp A PA Graber Jessica J Kuzmina Natalia A NA Huang Kai K Ksiazek Thomas G TG Crowe James E JE Bukreyev Alexander A
The Journal of infectious diseases 20181101 suppl_5
Screening of monoclonal antibodies against ebolaviruses requires small-animal models. Wild-type mice require adaptation of ebolaviruses, whereas immunodeficient mice are still resistant to nonadapted Bundibugyo ebolavirus. Swapping of Ebola virus glycoprotein with that from Bundibugyo virus resulted in a replication-competent chimeric virus, which caused 100% lethal infection in STAT1 knockout mice. Monoclonal antibody BDBV223 isolated from a human survivor of Bundibugyo virus infection protecte ...[more]
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