Stress-Induced Low Complexity RNA Activates Physiological Amyloidogenesis.
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ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC6249693 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Publications
Stress-Induced Low Complexity RNA Activates Physiological Amyloidogenesis.
Wang Miling M Tao Xianzun X Jacob Mathieu D MD Bennett Clayton A CA Ho J J David JJD Gonzalgo Mark L ML Audas Timothy E TE Lee Stephen S
Cell reports 20180801 7
Amyloid bodies (A-bodies) are inducible membrane-less nuclear compartments composed of heterogeneous proteins that adopt an amyloid-like state. A-bodies are seeded by noncoding RNA derived from stimuli-specific loci of the rDNA intergenic spacer (rIGSRNA). This raises the question of how rIGSRNA recruits a large population of diverse proteins to confer A-body identity. Here, we show that long low-complexity dinucleotide repeats operate as the architectural determinants of rIGSRNA. On stimulus, c ...[more]
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