Ontology highlight
ABSTRACT:
SUBMITTER: Iorgulescu JB
PROVIDER: S-EPMC6249768 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Iorgulescu J Bryan JB Braun David D Oliveira Giacomo G Keskin Derin B DB Wu Catherine J CJ
Genome medicine 20181122 1
Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape. ...[more]