Unknown

Dataset Information

0

Acquired mechanisms of immune escape in cancer following immunotherapy.


ABSTRACT: Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape.

SUBMITTER: Iorgulescu JB 

PROVIDER: S-EPMC6249768 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

Acquired mechanisms of immune escape in cancer following immunotherapy.

Iorgulescu J Bryan JB   Braun David D   Oliveira Giacomo G   Keskin Derin B DB   Wu Catherine J CJ  

Genome medicine 20181122 1


Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape. ...[more]

Similar Datasets

| S-EPMC8445627 | biostudies-literature
2022-04-10 | GSE167102 | GEO
| S-EPMC9399611 | biostudies-literature
| S-EPMC6474276 | biostudies-literature
| S-EPMC7763130 | biostudies-literature
| S-EPMC5459368 | biostudies-literature
| S-EPMC8333422 | biostudies-literature
| S-EPMC9133907 | biostudies-literature
| S-EPMC7108895 | biostudies-literature
| S-EPMC6164896 | biostudies-literature