Acquired mechanisms of immune escape in cancer following immunotherapy.
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ABSTRACT:
SUBMITTER: Iorgulescu JB
PROVIDER: S-EPMC6249768 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Acquired mechanisms of immune escape in cancer following immunotherapy.
Iorgulescu J Bryan JB Braun David D Oliveira Giacomo G Keskin Derin B DB Wu Catherine J CJ
Genome medicine 20181122 1
Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape. ...[more]
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