Ontology highlight
ABSTRACT:
SUBMITTER: Campbell GR
PROVIDER: S-EPMC6250054 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Campbell Grant R GR Bruckman Rachel S RS Chu Yen-Lin YL Trout Rodney N RN Spector Stephen A SA
Cell host & microbe 20181018 5
Long-lived resting memory CD4+ T cells (T<sub>CM</sub>) are a major reservoir of latent HIV infection. We hypothesized that latent HIV-T<sub>CM</sub> cells are maintained by aberrant expression of cell survival factors, including XIAP, BIRC2/cIAP1, and beclin-1. DIABLO/SMAC mimetics are therapeutic agents that compromise cell survival by hijacking host apoptotic machinery. We found that DIABLO/SMAC mimetics (birinapant, GDC-0152, and embelin) selectively kill HIV-T<sub>CM</sub> without increasin ...[more]