Ontology highlight
ABSTRACT:
SUBMITTER: Ohshima-Hosoyama S
PROVIDER: S-EPMC6250428 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Ohshima-Hosoyama Sachiko S Davare Monika A MA Prajapati Suresh I SI Abraham Jinu J Lal Sangeet S Nelon Laura D LD Kilcoyne Aoife A Giles Francis J FJ Hanes Martha A MA Rubin Brian P BP Keller Charles C
Journal of pediatric hematology/oncology 20120301 2
Overexpression of platelet-derived growth factor receptor alpha (PDGFR-A) has been documented in association with primary tumors and metastasis in medulloblastoma. Tumors from our genetically engineered sonic hedgehog-driven medulloblastoma mouse model overexpress PDGFR-A in primary tumors and thus this mouse model is a good platform with which to study the role of PDGFR-A in this central nervous system malignancy. We hypothesized that inhibition of PDGFR-A in medulloblastoma can slow or inhibit ...[more]