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Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population.

ABSTRACT: The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population.This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay.We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P?=?.015 and .009, respectively).Our results indicate that rs6776158 polymorphism that might elevate the risk of nephrolithiasis in the Chinese population.

SUBMITTER: Zhou H

PROVIDER: S-EPMC6250535 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Genetic polymorphism (rs6776158) in CaSR gene is associated with risk of nephrolithiasis in Chinese population.

Zhou Hai H Huang Huaxing H You Zebin Z Shadhu Kamleshsingh K Ramlagun Dadhija D Qiang Cao C Li Pu P Qi Lezhong L Shen Yuyong Y Zhou Ming M Chen Yuming Y Fei Shangchun S Wang Xiaoxiang X

Medicine 20181101 45

The objective of this study is to find about the association between calcium-sensing receptor (CaSR) genetic variants and susceptibility to nephrolithiasis in the Chinese Han population.This hospital-based case-control study included 319 nephrolithiasis cases and 378 healthy controls subjects. Two SNPs in CaSR were genotyped using the TaqMan assay.We found that subjects carrying the G allele of rs6776158 (AG and GG) had significantly higher risk of nephrolithiasis compared to the AA genotype (P ...[more]

PMID: 30407299

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