Liraglutide and Glycaemic Outcomes in the LEADER Trial.

ABSTRACT:

Introduction

The LEADER trial was a cardiovascular (CV) outcomes trial in patients with type 2 diabetes at high CV risk that compared liraglutide (n = 4668) with placebo (n = 4672) using a primary composite endpoint of 3-point major adverse CV events. The objective of this post hoc analysis was to investigate glycaemic outcomes across both treatment groups.

Methods

Glycated haemoglobin (HbA_1c) was measured at randomisation, month 3, month 6 and every 6 months thereafter. Cox regression was used to analyse time to a composite endpoint of glycaemic deterioration, defined as a specified change in HbA_1c or a substantial intensification of insulin or oral antihyperglycaemic drug (OAD). The individual components of the composite were also analysed.

Results

SUBMITTER: Zinman B 

PROVIDER: S-EPMC6250637 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature