Ontology highlight
ABSTRACT:
SUBMITTER: Wang F
PROVIDER: S-EPMC6250852 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Frontiers in aging neuroscience 20181116
Vascular dementia (VaD) is the second most common type of dementia after Alzheimer's disease (AD), characterized by progressive cognitive impairment, memory loss, and thinking or speech problems. VaD is usually caused by cerebrovascular disease, during which, cerebrovascular endothelial cells (CECs) are vulnerable. CEC dysfunction occurs before the onset of VaD and can eventually lead to dysregulation of cerebral blood flow and blood-brain barrier damage, followed by the activation of glia and i ...[more]