Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.
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ABSTRACT:
SUBMITTER: Chinta KC
PROVIDER: S-EPMC6250977 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Microanatomic Distribution of Myeloid Heme Oxygenase-1 Protects against Free Radical-Mediated Immunopathology in Human Tuberculosis.
Chinta Krishna C KC Rahman Md Aejazur MA Saini Vikram V Glasgow Joel N JN Reddy Vineel P VP Lever Jeremie M JM Nhamoyebonde Shepherd S Leslie Alasdair A Wells Ryan M RM Traylor Amie A Madansein Rajhmun R Siegal Gene P GP Antony Veena B VB Deshane Jessy J Wells Gordon G Nargan Kievershen K George James F JF Ramdial Pratistadevi K PK Agarwal Anupam A Steyn Adrie J C AJC
Cell reports 20181101 7
Heme oxygenase-1 (HO-1) is a cytoprotective enzyme that controls inflammatory responses and redox homeostasis; however, its role during pulmonary tuberculosis (TB) remains unclear. Using freshly resected human TB lung tissue, we examined the role of HO-1 within the cellular and pathological spectrum of TB. Flow cytometry and histopathological analysis of human TB lung tissues showed that HO-1 is expressed primarily in myeloid cells and that HO-1 levels in these cells were directly proportional t ...[more]
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