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Presence and diagnostic value of circulating tsncRNA for ovarian tumor.

ABSTRACT: tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at both transcriptional and post-transcriptional level. However, the presence of circulating tsncRNAs and their diagnostic potential is largely unclear. In this study, we investigate the serum-derived public transcriptome data from ovarian tumor patients and non-cancer controls, and find that circulating tsncRNAs cover a high proportion of total small RNA and are non-random degradation products in serum (ranging from 2.5-29.4%), which are enriched in several specific types of related tRNA (e.g., Gly-tRNA). Particularly, four tsncRNAs are differentially expressed in serum from cancer patients compared to those from healthy controls, and can predict abnormal cell proliferation with high accuracy. Our results reveal the ubiquitous presence of circulating tsncRNAs in serum, and diagnostic potential of specific tsncRNAs for ovarian tumor.

SUBMITTER: Peng EY

PROVIDER: S-EPMC6251159 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Presence and diagnostic value of circulating tsncRNA for ovarian tumor.

Peng Eric Y EY Shu Yang Y Wu Yuke Y Zeng Feier F Tan Shuangyan S Deng Yun Y Deng Yiqi Y Chen Haining H Zhu Lei L Xu Heng H

Molecular cancer 20181122 1

tRNA-derived small non-coding RNAs (tsncRNAs), a class of newly defined small non-coding RNA, have been considered to be involved in various cellular biological processes through regulating gene expression at both transcriptional and post-transcriptional level. However, the presence of circulating tsncRNAs and their diagnostic potential is largely unclear. In this study, we investigate the serum-derived public transcriptome data from ovarian tumor patients and non-cancer controls, and find that ...[more]

PMID: 30466461

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Presence and diagnostic value of circulating tsncRNA for ovarian tumor.

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Presence and diagnostic value of circulating tsncRNA for ovarian tumor.

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