Dataset Information

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.

ABSTRACT:

Background

Survivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stress disorder (PTSD) caseness in the first year following discharge from an intensive care unit (ICU).

Methods

Design: prospective multicentre follow-up study of survivors of ICU in the UK.

Setting

patients from 26 ICUs in the UK.

Inclusion criteria

patients who had received at least 24 h of level 3 ICU care and were 16 years of age or older.

Interventions

postal follow up: Hospital Anxiety and Depression Score (HADS) and the Post-Traumatic Stress Disorder (PTSD) Check List-Civilian (PCL-C) at 3 and 12 months following discharge from ICU.

Main outcome measure

caseness of anxiety, depression and PTSD, 2-year survival.

Results

In total, 21,633 patients admitted to ICU were included in the study. Postal questionnaires were sent to 13,155 survivors; of these 38% (4943/13155) responded and 55% (2731/4943) of respondents passed thresholds for one or more condition at 3 or 12 months following discharge. Caseness prevalence was 46%, 40% and 22% for anxiety, depression and PTSD respectively; 18% (870/4943 patients) met the caseness threshold for all three psychological conditions. Patients with symptoms of depression were 47% more likely to die during the first 2 years after discharge from ICU than those without (HR 1.47, CI 1.19-1.80).

Conclusions

Over half of those who respond to postal questionnaire following treatment on ICU in the UK reported significant symptoms of anxiety, depression or PTSD. When symptoms of one psychological disorder are present, there is a 65% chance they will co-occur with symptoms of one of the other two disorders. Depression following critical illness is associated with an increased mortality risk in the first 2 years following discharge from ICU.

Trial registration

ISRCTN Registry, ISRCTN69112866 . Registered on 2 May 2006.

SUBMITTER: Hatch R

PROVIDER: S-EPMC6251214 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.

Hatch Robert R Young Duncan D Barber Vicki V Griffiths John J Harrison David A DA Watkinson Peter P

Critical care (London, England) 20181123 1

<h4>Background</h4>Survivors of intensive care are known to be at increased risk of developing longer-term psychopathology issues. We present a large UK multicentre study assessing the anxiety, depression and post-traumatic stress disorder (PTSD) caseness in the first year following discharge from an intensive care unit (ICU).<h4>Methods</h4>Design: prospective multicentre follow-up study of survivors of ICU in the UK.<h4>Setting</h4>patients from 26 ICUs in the UK.<h4>Inclusion criteria</h4>pat ...[more]

PMID: 30466485

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Project description:BackgroundSurvivors of critical illness have significant psychopathological comorbidity. The treatments offered by primary health care professionals to affected patients are unstudied.AimTo report the psychological interventions after GPs received notification of patients who showed severe symptoms of anxiety, depression or Post-Traumatic Stress Disorder.MethodsDesign: Multi-centre prospective cohort sub-study of the ICON study.SettingNHS primary care in the United Kingdom.ParticipantsAdult patients, November 2006-October 2010 who had received at least 24 h of intensive care, where the general practitioner recorded notification that the patient had reported severe symptoms or caseness using the Hospital Anxiety and Depression Scale (HADS) or the Post-Traumatic Stress Disorder Check List-Civilian (PCL-C).InterventionsWe notified general practitioners (GPs) by post if a patient reported severe symptoms or caseness and sent a postal questionnaire to determine interventions after notification.Main outcome measurePrimary or secondary healthcare interventions instigated by general practitioners following notification of a patient's caseness.ResultsOf the 11,726 patients, sent questionnaire packs containing HADS and PCL-C, 4361 (37%) responded. A notification of severe symptoms was sent to their GP in 25% (1112) of cases. Of notified GPs, 65% (725) responded to our postal questionnaire. Of these 37% (266) had no record of receipt of the original notification. Of the 459 patients where GPs had record of notification (the study group for this analysis), 21% (98) had pre-existing psychopathology. Of those without a pre-existing diagnosis 45% (162) received further psychological assessment or treatment. GP screening or follow-up alone occurred in 18% (64) whilst 27% (98) were referred to mental health services or received drug therapy following notification.ConclusionsPostal questionnaire identifies a burden of psychopathology in survivors of critical illness that have otherwise gone undiagnosed following discharge from an intensive care unit (ICU). After being alerted to the presence of psychological symptoms, GPs instigate treatment in 27% and augmented surveillance in 18% of cases.Trial registrationISRCTN69112866 (assigned 02/05/2006).

Project description:RationaleChronically critically ill patients are often dependent on family members for surrogate decision-making, and these surrogates are at high risk for emotional distress. We hypothesized that patient- and surrogate-specific risk factors for surrogate post-traumatic stress disorder (PTSD) symptoms can be identified early in the course of chronic critical illness.ObjectivesTo identify risk factors for PTSD symptoms in surrogate decision-makers of chronically critically ill patients.MethodsWe performed a secondary analysis of the database from a multicenter randomized trial of a communication intervention for chronic critical illness patients and surrogates. Variables preselected for plausible mechanism for increasing PTSD symptoms and identifiable by Day 10 of mechanical ventilation were included in the analysis for association with surrogate PTSD symptoms at 90 days, as measured by the Impact of Events Score-Revised (IES-R). Patient factors included demographics, insurance status, baseline functional status, chronic comorbidities, illness severity, and presence of advance directive. Surrogate variables included demographics, education level and employment, religion, relationship to patient, and Hospital Anxiety and Depression Scale score measured at enrollment. Multivariable linear regression models were then constructed for 26 potential risk factors, including biologically or mechanistically plausible confounders for each, with IES-R score as the outcome. All models were adjusted for multiple respondents, using a mixed model, considering the patients as a random factor.ResultsOur analysis included 306 surrogates for 224 patients. A total of 49% of patients were female, and mean age was 59 years (95% confidence interval [CI], 56.4-60.7). A total of 71% of surrogates were female, and mean age was 51 years (95% CI, 49.3-52.4). After examining each potential risk factor in a separate multivariable model, only Day-10 surrogate Hospital Anxiety and Depression Scale score (? coefficient?=?1.02; 95% CI, 0.73-1.30) and patient unresponsiveness (? coefficient?=?8.39; 95% CI, 0.83-15.95) were associated with higher IES-R scores.ConclusionsAmong surrogate decision-makers for chronically critically ill patients, high anxiety and depression scores and patient unresponsiveness on or near Day 10 of mechanical ventilation are risk factors for PTSD symptoms at 90 days.

Dataset Information

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.

Background

Methods

Setting

Inclusion criteria

Interventions

Main outcome measure

Results

Conclusions

Trial registration

Publications

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study.

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