Ontology highlight
ABSTRACT:
SUBMITTER: Towner RA
PROVIDER: S-EPMC6251232 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Towner Rheal A RA Smith Nataliya N Saunders Debra D Brown Chase A CA Cai Xue X Ziegler Jadith J Mallory Samantha S Dozmorov Mikhail G MG Coutinho De Souza Patricia P Wiley Graham G Kim Kyeongsoon K Kang Shinwook S Kong Doo-Sik DS Kim Young-Tae YT Fung Kar-Ming KM Wren Jonathan D JD Battiste James J
Translational oncology 20181120 2
Treatment of glioblastoma (GBM) remains a challenge using conventional chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug resistance. We have assessed a novel nitrone-based agent, OKN-007, and found it to be effective in decreasing tumor volumes and increasing survival in orthotopic GBM xenografts by decreasing cell proliferation and angiogenesis and increasing apoptosis. In this study, we assessed combining OKN-007 with TMZ in vivo in a human G55 GBM orthotop ...[more]