Aspartate aminotransferase-to-platelet ratio index increases significantly 3 years prior to liver-related death in HIV-hepatitis-coinfected men.

ABSTRACT: : The utility of longitudinal AST-to-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown. We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIV+) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (P?=?0.10) and 30%/year during the 3 years predeath (P?

SUBMITTER: Price JC 

PROVIDER: S-EPMC6251714 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature