Ontology highlight
ABSTRACT:
SUBMITTER: Price JC
PROVIDER: S-EPMC6251714 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Price Jennifer C JC Seaberg Eric C EC Stosor Valentina V Witt Mallory D MD Lellock Carling D CD Thio Chloe L CL
AIDS (London, England) 20181101 17
: The utility of longitudinal AST-to-platelet ratio index (APRI), a surrogate for hepatic fibrosis, is unknown. We compared APRI up to 9 years before liver-related death among 57 cases of viral hepatitis-infected men (91% HIV+) to matched controls. APRI was stable among controls but, among cases, increased 4.6%/year from 9 to 3 years predeath (P = 0.10) and 30%/year during the 3 years predeath (P < 0.001). Thus, rapid APRI increase may predict impending liver-related death in HIV-viral hepatitis ...[more]