Ontology highlight
ABSTRACT:
SUBMITTER: Hoegl A
PROVIDER: S-EPMC6252082 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Hoegl Annabelle A Nodwell Matthew B MB Kirsch Volker C VC Bach Nina C NC Pfanzelt Martin M Stahl Matthias M Schneider Sabine S Sieber Stephan A SA
Nature chemistry 20181008 12
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in many central cellular processes. PLP-dependent enzymes (PLP-DEs) are ubiquitous and evolutionarily diverse, making their classification based on sequence homology challenging. Here we present a chemical proteomic method for reporting on PLP-DEs using functionalized cofactor probes. We synthesized pyridoxal analogues modified at the 2'-position, which are taken up by cells and metaboli ...[more]