Ontology highlight
ABSTRACT:
SUBMITTER: Kuhnle S
PROVIDER: S-EPMC6254356 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Kühnle Simone S Martínez-Noël Gustavo G Leclere Flavien F Hayes Sebastian D SD Harper J Wade JW Howley Peter M PM
The Journal of biological chemistry 20180926 47
Deregulation of the HECT ubiquitin ligase UBE3A/E6AP has been implicated in Angelman syndrome as well as autism spectrum disorders. We and others have previously identified the 26S proteasome as one of the major UBE3A-interacting protein complexes. Here, we characterize the interaction of UBE3A and the proteasomal subunit PSMD4 (Rpn10/S5a). We map the interaction to the highly conserved Zn<sup>2+</sup>-binding N-terminal (AZUL) domain of UBE3A, the integrity of which is crucial for binding to PS ...[more]