Long-term macrolide treatment for the prevention of acute exacerbations in COPD: a systematic review and meta-analysis.

ABSTRACT:

Background

Acute exacerbation of COPD (AECOPD) is associated with an increased hospitalization and mortality. Azithromycin and erythromycin are the recommended drugs to reduce the risk of exacerbations. However, the most suitable duration of therapy and drug-related adverse events are still a matter of debate. The aim of this meta-analysis was to assess the current evidence regarding the efficacy and safety of long-term macrolide treatment for COPD.

Materials and methods

We comprehensively searched PubMed, Embase, the Cochrane Library, and the Web of Science and performed a systematic review and cumulative meta-analysis of all randomized controlled trials (RCTs) and retrospective studies.

Results

Eleven RCTs and one retrospective study including a total of 2,151 cases

SUBMITTER: Cui Y 

PROVIDER: S-EPMC6254503 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature