Comprehensive genomic profiling identifies novel NTRK fusions in neuroendocrine tumors.
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ABSTRACT:
SUBMITTER: Sigal DS
PROVIDER: S-EPMC6254675 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Comprehensive genomic profiling identifies novel NTRK fusions in neuroendocrine tumors.
Sigal Darren S DS Bhangoo Munveer S MS Hermel Jonathan A JA Pavlick Dean C DC Frampton Garrett G Miller Vincent A VA Ross Jeffrey S JS Ali Siraj M SM
Oncotarget 20181109 88
CGP results from >60,000 cases were screened to identify NTRK fusion events from cases of neuroendocrine tumors. 2417 NET patients from diverse anatomic sites were identified. From this dataset, six cases harbored NTRK fusions which included intra- and inter-chromosomal translocations. A NTRK fusion frequency of approximately 0.3% was found across all subtypes of NETs. Three cases involved translocations of NTRK1 with unique fusion partners (GPATCH4, PIP5K1A, CCDC19). Co-occurring alterations oc ...[more]
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