Deep scanning lysine metabolism in Escherichia coli.
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ABSTRACT:
SUBMITTER: Bassalo MC
PROVIDER: S-EPMC6254735 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Publications
Deep scanning lysine metabolism in <i>Escherichia coli</i>.
Bassalo Marcelo C MC Garst Andrew D AD Choudhury Alaksh A Grau William C WC Oh Eun J EJ Spindler Eileen E Lipscomb Tanya T Gill Ryan T RT
Molecular systems biology 20181126 11
Our limited ability to predict genotype-phenotype relationships has called for strategies that allow testing of thousands of hypotheses in parallel. Deep scanning mutagenesis has been successfully implemented to map genotype-phenotype relationships at a single-protein scale, allowing scientists to elucidate properties that are difficult to predict. However, most phenotypes are dictated by several proteins that are interconnected through complex and robust regulatory and metabolic networks. These ...[more]
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