Ontology highlight
ABSTRACT:
SUBMITTER: Chin HS
PROVIDER: S-EPMC6255874 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Nature communications 20181126 1
Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act redundantly to drive apoptotic cell death. From an unbiased genome-wide CRISPR/Cas9 screen, we identified VDAC2 (voltage-dependent anion channel 2) as important for BAX, but not BAK, to function. Genetic deletion of VDAC2 abrogated the association of BAX ...[more]