Ontology highlight
ABSTRACT:
SUBMITTER: Morroni G
PROVIDER: S-EPMC6256782 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Morroni Gianluca G Brenciani Andrea A Brescini Lucia L Fioriti Simona S Simoni Serena S Pocognoli Antonella A Mingoia Marina M Giovanetti Eleonora E Barchiesi Francesco F Giacometti Andrea A Cirioni Oscar O
Antimicrobial agents and chemotherapy 20181126 12
Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ≥4 mg/liter). Epidemiological characterization demonstrated that the resistant isolates all belonged to different clones. Penicillin-binding protein (PBP) analysis showed substitutions in all PBPs and a novel insertion in PBP2a. The <i>m ...[more]