Unknown

Dataset Information

0

High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant Staphylococcus aureus Isolates from a Hospital in Central Italy.

ABSTRACT: Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant Staphylococcus aureus (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ?4?mg/liter). Epidemiological characterization demonstrated that the resistant isolates all belonged to different clones. Penicillin-binding protein (PBP) analysis showed substitutions in all PBPs and a novel insertion in PBP2a. The mecB and mecC genes were not detected. Ceftobiprole susceptibility screening is essential to avoid therapeutic failure and the spread of ceftobiprole-resistant strains.

SUBMITTER: Morroni G 

PROVIDER: S-EPMC6256782 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

High Rate of Ceftobiprole Resistance among Clinical Methicillin-Resistant <i>Staphylococcus aureus</i> Isolates from a Hospital in Central Italy.

Morroni Gianluca G   Brenciani Andrea A   Brescini Lucia L   Fioriti Simona S   Simoni Serena S   Pocognoli Antonella A   Mingoia Marina M   Giovanetti Eleonora E   Barchiesi Francesco F   Giacometti Andrea A   Cirioni Oscar O  

Antimicrobial agents and chemotherapy 20181126 12

Ceftobiprole is a fifth-generation cephalosporin with activity against methicillin-resistant <i>Staphylococcus aureus</i> (MRSA). One-year surveillance at the Regional Hospital of Ancona (Italy) disclosed a 12% ceftobiprole resistance rate (12/102 isolates; MIC, ≥4 mg/liter). Epidemiological characterization demonstrated that the resistant isolates all belonged to different clones. Penicillin-binding protein (PBP) analysis showed substitutions in all PBPs and a novel insertion in PBP2a. The <i>m  ...[more]

Similar Datasets

Unknown Methicillin-resistant staphylococcus aureus isolates in a hospital of shanghai.
| S-EPMC5351614 | biostudies-literature
Unknown In vitro selection and characterization of ceftobiprole-resistant methicillin-resistant Staphylococcus aureus.
| S-EPMC2415812 | biostudies-literature
Unknown Structural insights into the anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of ceftobiprole.
| S-EPMC3442540 | biostudies-literature
Transcriptomics Detection of mobile-genetic-element variation between colonizing and infecting hospital-associated methicillin-resistant Staphylococcus aureus isolates.
2012-10-29 | E-BUGS-128 | biostudies-arrayexpress
Unknown Clinical isolates of Staphylococcus intermedius masquerading as methicillin-resistant Staphylococcus aureus.
| S-EPMC535261 | biostudies-literature
Proteomics Resistant isolates of methicillin-resistant Staphylococcus aureus (MRSA)
2023-05-25 | MSV000092035 | MassIVE
Unknown Comparative analysis of multidrug-resistant, non-multidrug-resistant, and archaic methicillin-resistant Staphylococcus aureus isolates from Central Sydney, Australia.
| S-EPMC149719 | biostudies-literature
Unknown Matched-cohort DNA microarray diversity analysis of methicillin sensitive and methicillin resistant Staphylococcus aureus isolates from hospital admission patients.
| S-EPMC3527544 | biostudies-literature
Unknown Molecular characterization of methicillin-resistant Staphylococcus aureus isolates in Korea.
| S-EPMC3122668 | biostudies-literature
Unknown Draft Genome Sequences of Five Clinical Methicillin-Resistant Staphylococcus aureus Isolates and a Methicillin-Resistant Staphylococcus epidermidis Isolate.
| S-EPMC4520897 | biostudies-literature