Ontology highlight
ABSTRACT:
SUBMITTER: Dian S
PROVIDER: S-EPMC6256787 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Dian S S Yunivita V V Ganiem A R AR Pramaesya T T Chaidir L L Wahyudi K K Achmad T H TH Colbers A A Te Brake L L van Crevel R R Ruslami R R Aarnoutse R R
Antimicrobial agents and chemotherapy 20181126 12
High doses of rifampin may help patients with tuberculous meningitis (TBM) to survive. Pharmacokinetic pharmacodynamic evaluations suggested that rifampin doses higher than 13 mg/kg given intravenously or 20 mg/kg given orally (as previously studied) are warranted to maximize treatment response. In a double-blind, randomized, placebo-controlled phase II trial, we assigned 60 adult TBM patients in Bandung, Indonesia, to standard 450 mg, 900 mg, or 1,350 mg (10, 20, and 30 mg/kg) oral rifampin com ...[more]