Ontology highlight
ABSTRACT:
SUBMITTER: Cressey TR
PROVIDER: S-EPMC6256809 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20181126 12
We assessed tenofovir exposure during pregnancy and postpartum in hepatitis B virus (HBV)-infected HIV-uninfected women receiving tenofovir disoproxil fumarate (TDF) to prevent mother-to-child transmission of HBV. Data from 154 women who received TDF within a randomized controlled trial were included. Individual plasma tenofovir exposures (area under the concentration-time curve from 0 to 24 h [AUC<sub>0-24</sub>]) were estimated using a population pharmacokinetic approach. The estimated geometr ...[more]