Unknown

Dataset Information

0

Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.

ABSTRACT: This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.

SUBMITTER: Zhou WM 

PROVIDER: S-EPMC6257404 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.

Zhou Wei-Ming WM   He Rong-Rong RR   Ye Jian-Tao JT   Zhang Na N   Liu De-Yu DY  

Molecules (Basel, Switzerland) 20100324 4

This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil. ...[more]

Similar Datasets

Unknown Green synthesis and biological evaluation of novel 5-fluorouracil derivatives as potent anticancer agents.
| S-EPMC6921177 | biostudies-literature
Unknown Synthesis and Biological Screening of New Cyano-Substituted Pyrrole Fused (Iso)Quinoline Derivatives.
| S-EPMC8038376 | biostudies-literature
Unknown Design, Synthesis and Biological Evaluation of Novel 4-Substituted Coumarin Derivatives as Antitumor Agents.
| S-EPMC6225359 | biostudies-literature
Unknown Synthesis and biological evaluation of novel 2-methoxypyridylamino-substituted riminophenazine derivatives as antituberculosis agents.
| S-EPMC6271099 | biostudies-literature
Unknown Synthesis, biological evaluation and docking studies of 1,2,4-oxadiazole linked 5-fluorouracil derivatives as anticancer agents.
| S-EPMC8097950 | biostudies-literature
Unknown Synthesis and Biological Evaluation of 4β-N-Acetylamino Substituted Podophyllotoxin Derivatives as Novel Anticancer Agents.
| S-EPMC6491884 | biostudies-literature
Unknown Synthesis and Biological Evaluation of Three New Chitosan Schiff Base Derivatives.
| S-EPMC7301590 | biostudies-literature
Unknown Synthesis and biological evaluation of new pleuromutilin derivatives as antibacterial agents.
| S-EPMC6271455 | biostudies-literature
Unknown Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel ? opioid receptor ligands.
| S-EPMC4648120 | biostudies-literature
Unknown Synthesis and biological evaluation of new ligustrazine derivatives as anti-tumor agents.
| S-EPMC6268357 | biostudies-literature