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Comparison of dabigatran and warfarin used in patients with non-valvular atrial fibrillation: Meta-analysis of random control trial.


ABSTRACT:

Background

Dabigatran is a kind of oral anticoagulant and there was little review only about dabigatran and warfarin used in patients with atrial fibrillation. This meta-analysis only assesses the dabigatran and warfarin used in patients with atrial fibrillation.

Design

Cochrane Library, PubMed, Clinical Trials.gov, CNKI, and WanFang databases were searched. The primary endpoint was the incidence of stroke and the second endpoints were the incidence of bleeding and embolic events.

Results

Six RCTs and 20086 patients were included in our meta-analysis. No significant difference was obtained between 110?mg dabigatran and warfarin on the endpoint of stroke (risk ratio (RR), 0.90; 95% confidence interval [CI], 0.71-1.12; P?=?.34; I?=?0%) and embolic events p (RR, 0.89; 95% CI, 0.71-1.12; P?=?.32; I?=?0%). However, the 110?mg dabigatran associated lower incidence of bleeding (RR, 0.81; 95% CI, 0.69-0.95; P?=?.01; I?=?0%) compare with warfarin. When compared with 150?mg dabigatran, warfarin associated with lower rate of stroke (RR, 0.96; 95% CI, 0.83-1.12; P?=?.62; I?=?0%) and embolic events (RR, 0.67; 95% CI, 0.53-0.86; P?=?.001; I?=?0%) but similar in the incidence of bleeding (RR, 0.67; 95% CI, 0.53-0.86; P?=?.001; I?=?0%).

Conclusion

No significant difference was obtained between 110?mg dabigatran and warfarin in the incidence of stroke and embolic events. However, the 110?mg dabigatran associated lower incidence of bleeding compare with warfarin. When compared with 150?mg dabigatran, warfarin associated with lower incidence of stroke and embolic events but similar in the incidence of bleeding.

SUBMITTER: Yu YB 

PROVIDER: S-EPMC6257591 | biostudies-literature | 2018 Nov

REPOSITORIES: biostudies-literature

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Publications

Comparison of dabigatran and warfarin used in patients with non-valvular atrial fibrillation: Meta-analysis of random control trial.

Yu Yi-Bo YB   Liu Jing J   Fu Guo-Hua GH   Fang Ren-Yuan RY   Gao Fang F   Chu Hui-Min HM  

Medicine 20181101 46


<h4>Background</h4>Dabigatran is a kind of oral anticoagulant and there was little review only about dabigatran and warfarin used in patients with atrial fibrillation. This meta-analysis only assesses the dabigatran and warfarin used in patients with atrial fibrillation.<h4>Design</h4>Cochrane Library, PubMed, Clinical Trials.gov, CNKI, and WanFang databases were searched. The primary endpoint was the incidence of stroke and the second endpoints were the incidence of bleeding and embolic events.  ...[more]

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