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Glucocorticoid receptor control of transcription: precision and plasticity via allostery.


ABSTRACT: The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at genomic response elements. In turn, evidence suggests that context-driven plasticity is conferred by the integration of multiple signals, each serving as an allosteric effector of GR conformation, a key determinant of regulatory complex composition and activity. This structural and mechanistic perspective on GR regulatory specificity is likely to extend to other eukaryotic TRFs.

SUBMITTER: Weikum ER 

PROVIDER: S-EPMC6257982 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature

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Glucocorticoid receptor control of transcription: precision and plasticity via allostery.

Weikum Emily R ER   Knuesel Matthew T MT   Ortlund Eric A EA   Yamamoto Keith R KR  

Nature reviews. Molecular cell biology 20170105 3


The glucocorticoid receptor (GR) is a constitutively expressed transcriptional regulatory factor (TRF) that controls many distinct gene networks, each uniquely determined by particular cellular and physiological contexts. The precision of GR-mediated responses seems to depend on combinatorial, context-specific assembly of GR-nucleated transcription regulatory complexes at genomic response elements. In turn, evidence suggests that context-driven plasticity is conferred by the integration of multi  ...[more]

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