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Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials.


ABSTRACT: Extracellular matrix (ECM)-based implantable neural electrodes (NEs) were achieved using a microfabrication strategy on natural-substrate-based organic materials. The ECM-based design minimized the introduction of non-natural products into the brain. Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions, thereby reducing inflammatory strain fields in the tissue. Preliminary studies suggested that ECM-NEs produce a reduced inflammatory response compared with inorganic rigid and flexible approaches. In vivo intracortical recordings from the rat motor cortex illustrate one mode of use for these ECM-NEs.

SUBMITTER: Shen W 

PROVIDER: S-EPMC6258041 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature

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Extracellular matrix-based intracortical microelectrodes: Toward a microfabricated neural interface based on natural materials.

Shen Wen W   Karumbaiah Lohitash L   Liu Xi X   Saxena Tarun T   Chen Shuodan S   Patkar Radhika R   Bellamkonda Ravi V RV   Allen Mark G MG  

Microsystems & nanoengineering 20150629 1


Extracellular matrix (ECM)-based implantable neural electrodes (NEs) were achieved using a microfabrication strategy on natural-substrate-based organic materials. The ECM-based design minimized the introduction of non-natural products into the brain. Further, it rendered the implants sufficiently rigid for penetration into the target brain region and allowed them subsequently to soften to match the elastic modulus of brain tissue upon exposure to physiological conditions, thereby reducing inflam  ...[more]

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