Ontology highlight
ABSTRACT:
SUBMITTER: Laptenko O
PROVIDER: S-EPMC6258061 | biostudies-literature | 2016 Dec
REPOSITORIES: biostudies-literature
Laptenko Oleg O Tong David R DR Manfredi James J Prives Carol C
Trends in biochemical sciences 20160923 12
The p53 tumor suppressor is a transcription factor (TF) that exerts antitumor functions through its ability to regulate the expression of multiple genes. Within the p53 protein resides a relatively short unstructured C-terminal domain (CTD) that remarkably participates in virtually every aspect of p53 performance as a TF. Because these aspects are often interdependent and it is not always possible to dissect them experimentally, there has been a great deal of controversy about the CTD. In this r ...[more]